| ncRNA name | rno-miR-497 |
| ncRNA Category | miRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Rattus norvegicus |
| Tissues/Cell_line | retinas; primary rat Müller cells |
| Methods | qRT-PCR, Western blot, transfection, RNA immunoprecipitation assay (RIPA), RNA pull-down assay, luciferase reporter assay, flow cytometry |
| Expression pattern | up-regulated |
| Functional description | Under diabetic conditions, downregulated nuclear paraspeckle assembly transcript 1 decreased the expression of brain-derived neurotrophic factor through elevating miR-497, thereby promoting Müller cells apoptosis and aggravating diabetic retinopathy. |
| PubMed ID | 29383970 |
| Year | 2018 |
| Title | Long non-coding RNA nuclear paraspeckle assembly transcript 1 inhibits the apoptosis of retina Müller cells after diabetic retinopathy through regulating miR-497/brain-derived neurotrophic factor axis. |
| Drug-related ncRNA | NO |
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